News Medical

What is Gain-of-Function Research?

Gain-of-function research (GOFR) refers to the serial passaging of microorganisms to increase their transmissibility, virulence, immunogenicity, and host tropism by applying selective pressure to a ...
MIT Technology Review

“We never created a supervirus.” Ralph Baric explains gain-of-function research.

The work has helped in the development of mRNA coronavirus vaccines and the first approved covid drug. In May, the longtime coronavirus researcher Ralph Baric found himself at the center of the ...
STAT

Gain-of-function research advances knowledge and saves lives

Congress is considering a massive overhaul of the nation’s scientific enterprise, much of it in the name of ensuring competitiveness with China and other nations that are pouring billions into ...
The Conversation

Gain‑of‑function research is more than just tweaking risky viruses – it’s a routine and essential tool in all biology research

Seema Lakdawala receives funding from National Institutes of Health and the Flu Lab. Anice Lowen receives research funding from the National Institutes of Health and Flu Lab. The term “gain of ...
BMJ

Effectiveness of exercise for improving cognition, memory and executive function: a systematic umbrella review and meta-meta-analysis

Objective To evaluate systematic reviews of randomised controlled trials (RCTs) on the effects of exercise on general cognition, memory and executive function across all populations and ages. Methods ...
BMJ

Effects of exercise training on the cognitive function of older adults with different types of dementia: a systematic review and meta-analysis

Data sources Cochrane Central, PsycINFO, Embase, Medline and CINAHL. Eligibility criteria Peer-reviewed, randomised controlled trials, in English (1990–present), which examined the effects of exercise ...