Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic tangles overwhelm normal repair pathways, cells flip on a fast but error-prone ...
Once failed in high school chemistry due to a teacher’s judgement, Tomas Lindahl later reshaped the same discipline. Awarded the 2015 Nobel Prize in Chemistry for his pioneering DNA repair research, ...
The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer. LA JOLLA, CA—DNA repair proteins act like the body’s editors, ...
Illustration showing how autophagy induction increases the efficiency of precise gene editing. In normal cells, DNA breaks caused by CRISPR–Cas9 are frequently repaired through non-homologous end ...
Acute exercise triggers circulating changes that improve DNA damage repair and remodel gene expression in colon cancer cells, ...
Stanford Medicine researchers sifted through thousands of single nucleotide mutations in DNA to identify fewer than 400 that are functionally associated with inherited cancer risk. Thousands of single ...
The DNA of human cells consists of a sequence of about 3.1 billion building blocks. Cells go to great lengths to maintain the integrity of this vast store of information. They constantly untangle ...
DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...
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